Characters you take can influence which party members make it out of suicide mission. Here is a guide on who to take for skills.
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As we find out playing through, the insanity difficulty on Mass Effect 2 is... well, insanely difficult. While this is not only for insanity, it just applies heavily on the harder difficulties. On the suicide mission in particular, it is vitally important to pick the right characters as backup going into the base. If you choose the wrong ones and leave the defense line without enough defense, you can lose your party members, keeping you from the achievement and keeping them from coming into ME3.
Upon entering the mission, you will have to choose team members to do certain things. For the tech specialist needed to go through the ducts to disable security, Tali or Legion will work fine. You'll need to pick two people to lead groups. Miranda works well to lead the team when you start off, then the next time choose Garrus. When the crew members are saved and need to return to the ship, choose Miranda again. As the biotic specialist, Samara works well.
Now, to the actual battles... For completion on insanity mode, when the mission starts, choose the Collector Particle Beam Rifle as your heavy weapon and DO NOT use it unless you have to do so until the final fight, but we'll get to that later.
As far as weapons go, pick whichever your heart desires. This will not be an overly detailed description of the fights, so your own class specialization will determine certain things you do, but one recommendation will help plow through the collectors: take Mordin and Thane. Thane is great against collectors because of his statis being able to take down their barriers. Also, there are many ledges you will be fighting near during this mission, so if you flank then get Thane to do his throw ability, as long as the collector's barrier is gone he will go flying off and it saves you the trouble of killing him. Mordin works very well against them because of his incinerate. I would suggest mapping Mordin's incinerate and Thane's stasis to your two team member hotkeys so you can do them back-to-back with Thane taking out the barrier with stasis then Mordin incinerating them. It makes quick work of collectors.
Here are some tips to use for the duration of the mission:
1 - One more way to make this team combination deadlier is to set your settings so that team members do not use powers on their own so you have complete control of it.
2 - If you are using the Mordin/Thane combo, whenever facing a Scion, don't worry about targeting it directly with all of your fire. Keep shooting other enemies, but whenever powers recharge, keep nailing it with their stasis and incinerate powers.
3 - Always kill the Harbinger LAST. Whenever Harbinger takes control of a collector, it becomes increasingly difficult to kill. The offensive moves it has are powerful, but slow, so it's fairly easy to avoid them. Kill all the other collectors you see before killing the harbinger because if you kill the harbinger when other collectors are still around, it will just inhabit another one then another until there are no more collectors.
4 - When your tech specialist is crawling through the pipeline, keep your eye on the heat bar that appears. If you reach the checkpoint and there is still plenty of time left, keep going and kill a few enemies then return to activate the checkpoint. That way, you've already cleared some of the path to gain extra time for the bigger room you'll run into.
5 - If you haven't already got it, have your special power you can copy from another team member be a shield. Personally, I prefer Legion's tech shield because when it's all the way powered, you can choose the perk to do extra damage, but it's up to you. Then, hot-key the shield. You'll need it.
6 - Husks don't have to be shot to death. Once all the armor is gone and there is only health left, any altering attack will kill them. Examples: Throw, lift, cryo rounds, etc. They all kill husks without having their health all the way down, so if you have any of these, use them.
7 - Whenever there is a Collector Assassin (the one shooting you with a particle beam) kill it first. Your enemies are smart in insanity, but your team isn't always smart enough to hind behind cover.
8 - Direct your teammates. Tell them where to take cover to help prevent flanking. Keep them in close proximity because if they go too far away during a fight and an enemy flanks, they're dead.
9 - Take advantage of Shepard's ability to curve powers. If you have specializations that have powers such as incinerate or stasis, it helps to be able to arc them over the enemy's cover. (Just aim the cursor as high as it will go while still highlighting the enemy and fire it then it will curve down and hit them or go left/right to go around walls.)
Now for the boss fight:
Hopefully, you didn't spend too much of your heavy ammo, but fortunately, it's easy to get back. In the first part of this fight, don't worry about using your Particle Beam, but just shoot the cylinders holding the reaper up with a gun and it will fall. As the second part of the fight begins, the reaper will keep pulling itself up and you just shoot it where it glows - eyes and heart. The whole fight, the reaper will keep pulling itself up and falling down and enemies will also keep coming, but fortunately, no husks but only collectors/harbingers.
Now for tips on this fight:
1 - Any time the reaper is holding itself steady, hold the power menu and attack it with Mordin's incinerate and Thane's stasis. Since it's armor only, these attacks are effective.
2 - Keep your whole team where you start: On the center platform behind the first cover you see. Considering enemies come from the left and the right, your teammates will get flanked if they go to another cover. Also, the reaper blasts an attack that covers the entire platform, so you'll want to stay by cover to avoid it.
3 - Ignore all enemies if possible. Your team can kill them fairly easily and they'll keep coming until the fight is over. Just keep blasting the reaper's eyes or chest with the particle beam. The reason you want the particle beam is that the reaper falls without warning and moves about, so other weapons are not fast enough nor accurate enough to ensure you hit it all the time.
4 - If you run out of heavy ammo, kill a harbinger. It leaves heavy ammo behind. [That is only the case during this fight]
Following all of this, Suicide Mission
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